Immunogenicity Assays - Abzena

Immunogenicity Assays

Helping you to better understand your drug candidate.

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The evaluation of a drug candidate’s developability is a pivotal stage in the drug development process. Therapeutic antibodies and proteins can induce an immune response. Immunogenicity risk assessment is therefore a crucial aspect of biopharmaceutical drug development. Abzena’s experts offer immunogenicity assays, that help you better understand your drug.

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Although the potential for immunogenicity of therapeutic antibodies and proteins has been significantly reduced through the application of protein engineering technologies, clinical data shows that many biopharmaceuticals still induce an immune response in patients. Immunogenicity therefore remains a concern for companies developing new products and for the regulatory agencies asked to approve their use.

Our next-generation EpiScreen® 2.0 platform is Abzena’s innovative answer to these challenges. We utilize flow cytometry technology for precise, multi-dimensional immunogenicity assays. We provide a comprehensive suite of bioassays that predict and evaluate potential risks of preclinical immunogenicity in protein, antibody, and gene therapy therapeutics.

Smarter immunogenicity testing

When it comes time to evaluate the immunogenic risk of your biopharmaceutical program, our newly enhanced EpiScreen® 2.0 platform offers a comprehensive suite of assays that can predict, and evaluate potential risks of preclinical immunogenicity in protein, antibody, and gene therapy therapeutics.

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Discover EpiScreen® 2.0

EpiScreen® 2.0 – Ex vivo assessment of immunogenicity

EpiScreen® 2.0 encompasses a package of assays that allow an accurate and sensitive way to assess the potential immunogenicity of proteins and antibodies ex vivo using a variety of methods such as measuring CD4+ T cell responses, the primary drivers of memory-based immunogenicity or evaluating MHC Class II peptide presentation.

EpiScreen® 2.0 Time Course T Cell Assay

These assays have been used extensively as a standard for preclinical immunogenicity testing.

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EpiScreen® 2.0 DC:T Cell Assay

Assessing antibody immunogenicity and the 'adjuvant effect' of different product formulations on immunogenicity.

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Episcreen® 2.0 Cytokine Screen™

We can assess a biopharmaceutical product's immune modulating potential by assessing its ability to stimulate cytokine production.

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EpiScreen® 2.0 T Cell Epitope Mapping

Identifying CD4+ T cell epitopes within protein sequences in order to design deimmunized variants.

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EpiScreen® 2.0 MAPPs

Identifying MHC Class II bound peptides processed and presented by dendritic cells (DCs) from therapeutic proteins/mAbs.

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TCED™ & iTope-AI

A powerful tool for in silico immunogenicity assays and design of deimmunized proteins & antibodies.

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Custom Immunology Assays

Abzena brings together expertise in immunology with the technology required to perform bespoke immunology assays.

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Related Content

Blog: Immunogenicity Assessments – Frequently Asked Questions

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Abzena Launches EpiScreen® 2.0 Immunogenicity Platform

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IPI Article: Immunogenicity Management in Biologics

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Analytics & Bioassays

Our expertise in analytics and bioassays focuses on giving you the rapid insight to make informed decisions during your drug development journey.

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Analytical Method Development

Your product development program will be accelerated by leveraging our expansive in-house capabilities, technologies, and knowledge to deliver methods tailored to your molecule of interest.

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Cell Line Development

Leveraging our experience in accelerating biological product development, we generate cell lines with high productivity and the right product quality.

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Formulation Development

With a focus on aligning your drug candidates to the ideal target product profile (TPP) we develop a comprehensive range of formulation development packages.

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