Custom Immunology Assays

Abzena are ready to work in partnership with you to provide custom immunology solutions, utilizing technical expertise and a large selection of available technologies.

Our large bank of characterized PBMC, regulated by the human tissue authority, supplies fresh whole blood, buffy coats, apheresis cones and leukopaks, as well as a large range of cell lines can be used for collaborative studies. Cross-group collaborations are particularly effective.

Abzena have expertise encompassing the breadth of biologic developability working synergistically across departments to progress pre-clinical programs.

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Custom immunology assays can be set up using a choice of test system, stimulant and readout. Contact our team of experts to discuss options for your program.

 

 

Examples of recent custom and technology development projects:

  • A study using primary dendritic cells to assess the functionality of a complex novel therapeutic.
  • Study of B cell functionality with CD40 ligand activation.
  • Binding, ADCC, and apoptosis assays using isolated eosinophils.
  • Identifying viral epitopes using MAPPs, in silico, CD8+ DC: T cell assay, and FluoroSpot.
  • Functional assays for bispecific antibodies.
  • T cell-specific cell killing assay for bispecific antibodies using live cell imaging.
  • Study into the effect of drug candidates on dendritic cell maturation and migration.
  • Assessment of neutrophil activation – migration assay and ROS and MPO release measurement.

Types of cells:

  • Primary dendritic cells
  • CD25 + depleted CD4+ T cells
  • CD8+ T cells
  • B cells
  • Eosinophils
  • NK cells
  • PBMC
  • Neutrophils
  • T and B cell lines
  • Extensive selection of cell lines at Abzena

Modalities tested:

  • Antibody-drug conjugates
  • Bi-specifics, tri-specifics
  • Cytokine fusions
  • Cytokine receptor Antagonists
  • Checkpoint inhibitors
  • Chemokine Receptor
  • Enzymes
  • Fragments
  • Nanobodies (VHH)
  • Signaling receptor inhibitors
  • TLR agonists
  • Viral proteins
  • Therapeutic peptides