Complex Biologics CDMO+ CRO - Abzena

Custom Immunology Assays

Our experts have over 20 years of experience in immunoassay development. Start smarter, with Abzena.

Custom immunology assays can be set up using a choice of test system, stimulant and readout. Contact our team of experts to discuss options for your program.

Abzena are ready to work in partnership with you to provide custom immunology solutions, utilizing technical expertise and a large selection of available technologies.

Our large bank of characterized PBMC, regulated by the human tissue authority, supplies fresh whole blood, buffy coats, apheresis cones and leukopaks, as well as a large range of cell lines can be used for collaborative studies. Cross-group collaborations are particularly effective.

Abzena have expertise encompassing the breadth of biologic developability working synergistically across departments to progress pre-clinical programs.

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Examples of recent custom and technology development projects:

  • A study using primary dendritic cells to assess the functionality of a complex novel therapeutic.
  • Study of B cell functionality with CD40 ligand activation.
  • Binding, ADCC, and apoptosis assays using isolated eosinophils.
  • Identifying viral epitopes using MAPPs, in silico, CD8+ DC: T cell assay, and FluoroSpot.
  • Functional assays for bispecific antibodies.
  • T cell-specific cell killing assay for bispecific antibodies using live cell imaging.
  • Study into the effect of drug candidates on dendritic cell maturation and migration.
  • Assessment of neutrophil activation – migration assay and ROS and MPO release measurement.

Types of cells:

  • Primary dendritic cells
  • CD25 + depleted CD4+ T cells
  • CD8+ T cells
  • B cells
  • Eosinophils
  • NK cells
  • PBMC
  • Neutrophils
  • T and B cell lines
  • Extensive selection of cell lines at Abzena

Modalities tested:

  • Antibody-drug conjugates
  • Bi-specifics, tri-specifics
  • Cytokine fusions
  • Cytokine receptor Antagonists
  • Checkpoint inhibitors
  • Chemokine Receptor
  • Enzymes
  • Fragments
  • Nanobodies (VHH)
  • Signaling receptor inhibitors
  • TLR agonists
  • Viral proteins
  • Therapeutic peptides
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EpiScreen® 2.0 Time Course T Cell Assay

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Episcreen® 2.0 Cytokine Screen™

We can assess a biopharmaceutical product's immune modulating potential by assessing its ability to stimulate cytokine production.

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