Bioconjugates & Chemistry: Complex Chemistry & Polymers - Abzena

Bioconjugates & Chemistry: Complex Chemistry & Polymers

We have a strong background in bioconjugate chemistry & extensive experience of custom synthesis. Explore how Abzena’s end-to-end chemistry services can keep your bioconjugate moving forward.

Tailored chemistry solutions for your therapeutics.

Complex payloads, hydrophobic linkers, and polymer conjugates ask more of a synthesis team than standard small-molecule routes. To meet your program goals, we develop novel and improve existing synthetic routes for complex chemicals, cytotoxins, payloads, linkers, HPAPI, biopolymers, and nanoparticles. We design, evaluate, and execute state-of-the-art synthetic strategies to deliver quality molecules with chiral integrity.

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We offer product development and formulation programs to accelerate your timelines by leveraging our comprehensive in-house capabilities, technologies, and knowledge to deliver processes tailored to your molecule of interest.

We ensure the purity and integrity of your products by offering an extensive range of capabilities in the analytical method development (AMD) and QC departments.

We utilize quality by design (QbD) principles and follow ICH Product Lifecycle guidelines to develop processes for manufacturing at toxicology, clinical, and commercial scale.

For ADC, AOC, or RDC programs that arrive with existing methods, the team can execute seamless tech transfer or build an entirely new route when efficiency or safety demands it.

Our knowledge of cGMP manufacturing enables us to successfully transfer existing processes into our facilities or develop a new innovative process, when needed, to meet your program needs.

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Complex Chemistry & Polymer Services

Abzena partners with you for seamless bioconjugate and chemistry projects, start to finish. Elevate development with our expertise, including bioconjugation and ADC services.

Complex Chemistry

To meet your program goals, we design novel and improve existing synthetic routes for complex chemicals, cytotoxins, payloads, linkers, HPAPI, and biopolymers.

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Polymer Conjugate Formulation

With extensive experience in the synthesis of synthetic polymers and conjugation, our scientists design, deliver and test polymer-based nanoparticles for your program needs.

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Analytical Method Development & Validation

Your product development program will be accelerated by leveraging our extensive in-house capabilities, technologies, and knowledge to deliver methods tailored to your molecule of interest.

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Formulation Development

We develop comprehensive formulation development packages including stable liquid and lyophilized formulations for bioconjugates.

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Process Development & Optimization

Our experts collaborate together to develop quality, commercially viable processes ensuring seamless scale up through to commercial launch.

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Highly Potent Materials

Utilizing a combination of technology, infrastructure, and expertise, we provide you with seamless, flexible highly potent API development and manufacturing tailored to your specific needs.

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Complex Chemistry for Antibody-Drug Conjugates (ADCs)

The development of antibody-drug conjugates (ADCs) and other bioconjugates requires a highly specialized chemistry team of experts. At Abzena, we have over 20 years of experience in complex chemistry, providing end-to-end support for the entire ADC lifecycle from discovery and design to development and clinical manufacturing.

Discover our complex chemistry expertise, including the design and synthesis of complex molecules such as cytotoxins and other linker payloads, for ADCs by downloading our info sheet today.

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Let’s move medicine forward - Abzena

Let's move medicine forward.

Whether you need a novel linker-payload, a pegylated nanoparticle, or an HPAPI manufactured under containment, the same end-to-end mindset applies tailored chemistry, rigorous control, and a direct line from first flask to validated commercial process. We adapt our approach to shorten lead times and develop risk mitigation strategies to ensure your overall success in delivering vital medicines to patients.

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