Abzena Bristol, PA, USA Facility

Abzena Bristol, PA, USA

Specializing in bioconjugation, linker-payloads, highly potent materials & complex chemistry.

Bristol, PA, USA

At Abzena Bristol, we specialize in bioconjugation, quality linker payloads, highly potent materials and complex chemistry.

Over two decades of expertise in delivering bioconjugates for first-in-human studies and beyond:

  • Chemistry Development
  • Conjugation Development
  • Analytical & Process Development
  • cGMP Manufacturing & Stability

Address

360 George Patterson Blvd, Bristol, PA,19007, USA

+1 215-788-3603

 

Our Bristol, PA facility provides preclinical through commercial manufacturing support for bioconjugate drug programs including antibody-drug conjugates (ADCs), antibody-oligonucleotide conjugates (AOCs), Radio-conjugates (RDCs) and Peptide-conjugates (PDCs).  With specialized handling controls in place to work with highly potent and cytotoxic materials, we can provide end-to-end development and manufacturing support for these innovative therapeutics.

Facility Highlights:

  • Purpose-built facility which uniquely combines single site process scale-up and GMP manufacture up to commercial scale of conjugation, linkers, payloads, and linker payloads​​
  • Expertise in integrated and standalone activities supporting ADC IND and CTA programs for ADC​​
  • In early 2024, completed ~$1.6MM facility and lab renovation​​
  • Bioconjugation batch scale of 500g (equipment procurement spec’ed to scale to 6kg), payload-linker at 100L scale (currently evaluating chemistry reactor scale up to 200L)​

Key Capabilities

Payload / Linker-Payload / Complex Small Molecule Synthesis

  • Synthesize commonly known, as well as custom designed, linker-payloads using a toolbox approach to maximize number of compounds generated in shortest time
  • Skilled in synthesis of complex molecules and novel payloads​
  • Develop and handle large quantities highly potent APIs

Expertise in high-quality bioconjugates

  • Expert ADC design and construction
  • Additional conjugation services, such as conjugated vaccine, protein cross-linking, oligo- and liposome- bioconjugation, PEGylation and nanoparticles

Process development and optimization

  • Design and optimization of synthetic routes that provide an efficient, scalable, and robust process for production of both non-GMP and cGMP payloads, payload-linker and complex small molecule production

cGMP Manufacturing

  • GMP manufacturing of final ADC conjugates and other bioconjugates for preclinical, Phase 1/2 clinical trials
  • GMP suite utilizes single-use technology in the bioconjugation suite

Discover Abzena Bristol

Watch our video below to learn more about our Bristol, PA facility.