Accelerating and de-risking the development and manufacture of your next-generation therapies, our integrated approach supports the lifecycle of ADC discovery and development including the design and synthesis of payload-linker constructs for ADCs and conjugates.
Offering a comprehensive approach, we use a matrix evaluation and developability approach to streamline the development, scale, and manufacture of your challenging payloads, linkers and payload-linker chemical intermediates for ADCs and other conjugates for your discovery and preclinical programs.
Expertise in design includes:
Expertise in optimization of:
With a focus on simplifying synthetic routes we have designed and synthesized thousands of payloads.
We create efficiencies by identifying the most suitable linkers for superior ADC profiles.
Our integrated approach includes a bioconjugation team that can quickly conjugate novel payloads and payload-linker constructs and evaluate the resulting ADCs.
Extensive Experience
Extensive experience with the design, synthesis and SAR development of payloads for ADCs including:
