Abzena Bristol, PA, USA Facility

Abzena Bristol, PA, USA

Specializing in bioconjugation, linker-payloads, highly potent materials & complex chemistry.

Bristol, PA, USA

At Abzena Bristol, we specialize in bioconjugation, quality linker payloadshighly potent materials and complex chemistry.

Over two decades of expertise in delivering bioconjugates for first-in-human studies and beyond:

  • Chemistry Development
  • Conjugation Development
  • Analytical Development
  • cGMP Manufacturing & Stability

Address

360 George Patterson Blvd, Bristol, PA,19007, USA

+1 215-788-3603

 

Our Bristol, PA facility provides preclinical through commercial manufacturing support for bioconjugate drug programs including antibody-drug conjugates (ADCs), antibody-oligonucleotide conjugates (AOCs), Radio-conjugates (RDCs) and Peptide-conjugates (PDCs).  With specialized handling controls in place to work with highly potent and cytotoxic materials, we can provide end-to-end development and manufacturing support for these innovative therapeutics.

Facility Highlights:

  • Purpose-built facility which uniquely combines single site process scale-up and GMP manufacture up to commercial scale of conjugation, linkers, payloads, and linker payloads​
  • Expertise in integrated and standalone activities supporting ADC IND and CTA programs for ADC​
  • In early 2024, completed ~$1.6MM facility and lab renovation​
  • Bioconjugation batch scale of 500g (equipment procurement spec’ed to scale to 6kg), payload-linker at 100L scale (currently evaluating chemistry reactor scale up to 200L)​

Key Capabilities

  • Payload / Linker-Payload / Complex Small Molecule Synthesis
    • Synthesize commonly known, as well as custom designed, linker-payloads using a toolbox approach to maximize number of compounds generated in shortest time​
    • Skilled in synthesis of complex molecules and novel payloads​
    • Develop and handle large quantities highly potent APIs
  • Expertise in high-quality bioconjugates
    • Expert ADC design and construction ​
    • Additional conjugation services, such as conjugated vaccine, protein cross-linking, oligo- and liposome- bioconjugation, PEGylation and nanoparticles
  • Process development & optimization
    • Design and optimization of synthetic routes that provide an efficient, scalable, and robust process for production of both non-GMP and cGMP payloads, payload-linker and complex small molecule production
  • cGMP Manufacturing
    • GMP manufacturing of final ADC conjugates and other bioconjugates for preclinical, Phase 1/2 clinical trials
    • GMP suite utilizes single-use technology in the bioconjugation suite

Discover Abzena Bristol

Watch our video below to learn more about our Bristol, PA facility.