Scientific Poster: ThioBridge as a Tool for ADCs

Access our recent poster from WADC London 2024 entitled: ‘ThioBridge® as a Tool for the Design, Optimization & Manufacture of ADCs’.

Our ThioBridge® conjugation technology makes use of naturally occurring interchain disulfide bonds of an antibody to generate antibody-drug conjugates (ADCs).

ThioBridge® offers several key features including homogeneity with high conversion to a single DAR species, stability as the linker does not deconjugate or cross-conjugate and site-specificity due to conserved location of conjugation.

ThioBridge® is compatible across a variety of modalities and can incorporate novel linker architecture allowing further optimization of ADCs across a broader range of antibody-drug combinations.

Poster authors include Richard J. Spears*, Ruslan Grygorash, Johanna Midelet, Gavin Birch, Bebiana Sousa, Ben Sawyer, Joao Nunes, William McDowell, Fabio Rossi, Nicolas Camper*, Robert Holgate,
Campbell Bunce 

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