AbZelectPRO™: Improving Cell Line Development Efficiency

Move your cell line development efficiency forwards with our AbZelectPRO™ platform.

To progress innovative new biologic therapeutics from development to clinical phases, it is essential for developers to prove that the drug can be consistently manufactured while meeting quality standards. In the United States, this is done through the submission of an Investigational New Drug Application (IND) to the Food and Drug Administration (FDA).

Developers face pressure from stakeholders and investors to quickly submit IND applications and show a return on investment. However, mammalian cell line development (CLD) often poses a challenge, sometimes taking up to a year to establish a stable cell line.

Why choose AbZelectPRO™?

Abzena’s AbZelectPRO™ platform provides a solution by simplifying CLD, reducing lead candidate sequence to research cell bank generation timelines to 10 weeks, and minimizing risks for future processes to enhance efficiency.

Benefits of AbZelectPRO™ with 2G UNic vector technology

For more complex biologic programs, we can deliver increased productivity by enhancing our AbZelectPRO™ platform, which combines our existing CHO cell line with ProteoNic’s premium expression vector technology 2G UNic.

• Optimized expression cassettes to maximize productivity from each cell
• Efficient GS selection marker compatible with current AbZelectPRO™ CHO Cell Line
• Proven track record – ProteoNic are moving towards regulatory approvals with multiple programs in the clinic and work with several large pharmaceutical firms.
• Early material from highly productive stable pools for antibodies, bispecifics and fusion proteins
• Higher frequency of high-producing clones offering more shots on goal- up to 8 g/L
• Highly stable clones maintaining productivity beyond 60 generations
• Quicker doubling times with a >30% reduction in cell line development timelines
• Uses single-use bioreactors to lower production costs
• Robust scalable and consistent platform process
• Further process intensification can boost titres to achieve 10g/L at scale
• Enhanced cycle times with faster growth with optimized CHO-K1 host cell line

Abzena’s Cell Line Development Expertise

As a life science contract development and manufacturing organization (CDMO) with over two decades of experience in cell line development, Abzena has expertise in expressing biologics ranging from antibodies, antibody fragments, fusion proteins, and vaccines.

Discover our cell line development (CLD) services.

Download our info sheet today to learn more about the potential benefits of our AbZelectPRO™ technology platform.

Download Info Sheet