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Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids

Natural products have been used for many medicinal purposes for centuries. Antibody drug conjugates (ADCs) have utilized this rich source of small molecule therapeutics to produce several clinically useful treatments. ADCs based on the natural product maytansine have been successful clinically. The authors further the utility of the anti-cancer natural product maytansine by developing efficacious […]... Read more

Design and Synthesis of Isoquinolidinobenzodiazepine Dimers, a Novel Class of Antibody–Drug Conjugate Payload

Antibody–drug conjugates (ADCs) represent an important class of emerging cancer therapeutics. Recent ADC development efforts highlighted the use of pyrrolobenzodiazepine (PBD) dimer payload for the treatment of several cancers. We identified the isoquinolidinobenzodiazepine (IQB) payload (D211), a new class of PBD dimer family of DNA damaging payloads. We have successfully synthesized all three IQB stereoisomers, […]... Read more

Modulation of drug-linker design to enhance in vivo potency of homogeneous antibody-drug conjugates

Antibody-drug conjugates (ADCs) are a promising class of anticancer agents which have undergone substantial development over the past decade and are now achieving clinical success. The development of novel site-specific conjugation technologies enables the systematic study of architectural features within the antibody conjugated drug linker that may affect overall therapeutic indices. Here we describe the […]... Read more

Propagating a Full Spectrum of Services for ADC Development and Manufacture

Download the article in full here The development and manufacture of antibody-drug conjugates (ADCs) requires expertise in both biological drug substance and chemical active pharmaceutical ingredient (API) technologies. The need for contract development and manufacturing organizations (CDMOs) to provide the full spectrum of services for this rapidly growing drug type for enhanced patient treatment is […]... Read more

A deimmunised form of the ribotoxin, α-sarcin, lacking CD4+ T cell epitopes and its use as an immunotoxin warhead

Fungal ribotoxins that block protein synthesis can be useful warheads in the context of a targeted immunotoxin. α-Sarcin is a small (17 kDa) fungal ribonuclease produced by Aspergillus giganteus that functions by catalytically cleaving a single phosphodiester bond in the sarcin–ricin loop of the large ribosomal subunit, thus making the ribosome unrecognisable to elongation factors […]... Read more

Building a biologics capabilities network

This article explains how Abzena is building a biologics capabilities network through a slew of acquisitions. GEN May 15, 2016 (Vol. 36 No.10) Read more

The INNs and outs of antibody nonproprietary names Tim D. Jones, Paul J. Carter, Andreas Plückthun, Max Vásquez, Robert G.E. Holgate, Isidro Hötzel, Andrew G. Popplewell, Paul W.H.I. Parren, Markus Enzelberger, Hendrik J. Rademaker, Michael R. Clark, David C. Lowe, Bassil I. Dahiyat, Victoria Smith, John M. Lambert, Herren Wu, Mary Reilly, John S. Haurum, Stefan Dübel, James S. Huston, Thomas, Schirrmann, Richard A.J. Janssen, Martin […]... Read more

A comparison of the ability of the human IgG1 allotypes G1m3 and G1m1,17 to stimulate T-cell responses from allotype matched and mismatched donors.

Carl I. Webster, Christine J. Bryson, Edward A. Cloake, Tim D. Jones, Mark J. Austin, Anette C. Karle, Sebastian Spindeldreher, David C. Lowe & Matthew P. Baker. mAbs, Volume 8, Issue 2, 2016 ABSTRACT The immunogenicity of clinically administered antibodies has clinical implications for the patients receiving them, ranging from mild consequences, such as increased clearance of […]... Read more

Characterisation of a novel anti-CD52 antibody with improved efficacy and reduced immunogenicity

Holgate RGE, Weldon R, Jones TD, Baker MP (2015) Characterisation of a Novel Anti-CD52 Antibody with Improved Efficacy and Reduced Immunogenicity. PLoS ONE 10(9): e0138123. doi:10.1371/journal.pone.0138123 Abstract Anti-CD52 therapy has been shown to be effective in the treatment of a number of B cell malignancies, hematopoietic disorders and autoimmune diseases (including rheumatoid arthritis and multiple sclerosis); however the […]... Read more

In vitro and in vivo evaluation of cysteine rebridged trastuzumab–MMAE antibody drug conjugates with defined drug-to-antibody ratios

Penny Bryant, Martin Pabst, George Badescu, Matthew Bird, William McDowell, Estera Jamieson, Julia Swierkosz, Kosma Jurlewicz, Rita Tommasi, Korinna Henseleit, XiaoBo Sheng, Nicolas Camper, Anais Manin, Katarzyna Kozakowska, Karolina Peciak, Emmanuelle Laurine, Ruslan Grygorash, Andrew Kyle, David Morris, Vimal Parekh, Amrita Abhilash, Ji-won Choi, Jeff Edwards, Mark Frigerio, Matthew P. Baker, and Antony Godwin Abstract […]... Read more

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