Mastering the Art of Developing a Successful Bispecific Antibody

Transitioning from single-functional antibodies to sophisticated bispecific designs not only introduces unique challenges but also demands innovative approaches. Unlike traditional antibodies, bispecifics require carefully tailored screening strategies in order to identify the most effective format.

Watch our on-demand webinar today to gain valuable insights into the strategies and methodologies that can help you successfully navigate the complexities of bispecific antibody development.

In this comprehensive webinar, we thoroughly explore the principles and practices of developing successful bispecific antibodies. Specifically, we delve into intelligent bispecific design, focusing on key factors such as avidity, spacing, and the formatting of fragment antigen binding (Fab) and single-chain fragment vehicle (scFv) arms. Our systematic approach aims to streamline the screening process, allowing for broad exploration while maintaining minimal designs.

You will learn about:

• Key Design Considerations for Bispecific Candidates: Discover what elements to include and avoid in order to optimize your designs
• Efficiently Improving Purity with Single-Step Purification: Uncover methods to enhance antibody purity efficiently
• In-Depth Case Study on Screening Strategies: Gain an understanding of the importance of screening multiple designs through a detailed case study

Our Expert Speaker

Timothy Wood, PhD, Senior Scientist, Abzena

Dr. Timothy Wood is an accomplished scientist with a robust background in technology development, honed through a PhD from the University of Edinburgh and postdoctoral research at prestigious institutions, including Brown University and the University of Cambridge.

With five years of experience in the biotech sector focused on Affimer-based therapeutics, Tim has been contributing his expertise at Abzena for over two years. As a Senior Scientist in the Protein Engineering team, he has led diverse projects in de-immunization, affinity maturation and the design and production of bispecific antibodies, demonstrating a broad and impactful skill set in the field.