Linker Payload Services -Abzena

Linker Payload

We are experts at selecting the optimal payload-linker construct. Discover our bioconjugate & ADC payload-linker services.

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Maximize your bioconjugate candidate with unmatched precision

70 linker payloads designed and synthesized including ADC payloads.

>17 drug-linked & small molecule process development programs completed & transferred to GMP.

State-of-the-art preclinical through commercial ADC manufacturing capabilities at Bristol, PA.

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Linker payload architecture is fundamental to the successful design of your drug candidate. Developing a safe and effective ADC drug requires the assembly of the desirable linker with the payload and the monoclonal antibody (mAb). Our extensive knowledge regarding mAbs, linkers, and payloads ensures a robust lead drug candidate.

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A well designed linker helps the antibody to selectively deliver and release the drug to the tumor site. Our tailored solutions identify and de-risk your clinical candidates for development ensuring stage-specific milestones are met. By applying our expertise in highly potent small molecule process development, we utilize a Design of Experiment (DOE) based approach. Our capabilities include:

  • 100ml to 100L jacketed glass reactors allowing for efficient scale-up and ability to develop accurate scale-down models
  • Non-chromatographic purification methods such as precipitation and crystallization
  • Teledyne-Isco Torrent medium pressure chromatography systems capable of both normal and reversed phase purification up to 3.8kg columns
  • Novasep Hipersep high pressure chromatography skids capable of batch purification of more than 1kg of material in a single processing day

Leverage our advanced linker payload solutions.

We are dedicated to advancing the frontiers of medicine through our specialized linker payload solutions for bioconjugates and ADCs. Our comprehensive suite of services encompasses everything from precise payload design to GMP manufacturing, backed by a deep understanding of monoclonal antibodies and innovative linker technologies.

Linker Payload Services

To accelerate lead drug candidate selection, we apply our knowledge in linker payload design and synthesis, high potency materials, and analytical method development to develop your complex ADCs.

Linker Payload Design & Synthesis

Supporting your candidate ranking and lead selection process, we determine the optimal design of linker payload architecture and profiling in a series of in silico, ...

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Analytical Method Development

Your product development program will be accelerated by leveraging our extensive in-house capabilities, technologies, and knowledge to deliver methods tailored to your molecule of interest.

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Highly Potent Materials

Utilizing a combination of technology, infrastructure, and expertise, we provide you with seamless, flexible highly potent API development and manufacturing tailored to your specific needs.

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Tailored processes, reliably delivered

Linker-payload processes are developed and transferred directly to our cGMP manufacturing team minimizing challenges seen during process transfers.

We develop the most effective processes for manufacturing at toxicology, clinical, and commercial scale using quality by design (QbD) principles.

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Our expert knowledge of cGMP manufacturing enables us to successfully transfer existing processes into our facilities or develop a new innovative process, when needed, to meet your program needs.

Processes follow ICH Product Lifecycle guidelines which ensure a robust and well characterized scalable manufacturing process.

Utilizing analytics, we ensure the right product quality attributes for your program.

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“We required a partner who not only shared our commitment to innovation but also possessed the deep technical expertise necessary to guide us through the complexities of ADC development. Abzena has been that partner for us. From the initial stages of linker payload design to the final steps of regulatory submission, their team has demonstrated exceptional proficiency and dedication. Working with Abzena, we have been impressed by their ability to integrate sophisticated design with rigorous analytical validation, all while maintaining a clear focus on regulatory compliance. Their proactive communication and adaptability have been particularly invaluable, ensuring that our projects not only meet but exceed the rigorous standards required in our field.”

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Let’s move medicine forward.

The asset you’re developing right now can make a real difference for human health. Let us apply our wealth of experience to accelerate and maximize its potential.

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