Cell Line Development Services - Abzena

Cell Line Development

AbZelectPRO™ is our cell line development solution. It can rapidly progress therapeutic protein & recombinant vaccine programs from DNA to RCB in 10 weeks.

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We are moving cell line development forward

Go from DNA to RCB in just 10 Weeks with AbZelectPRO™

Go from DNA to RCB in just 10 Weeks with AbZelectPRO™

CLD Services - Reducing cell line development timelines by 30%

Reducing CLD development timelines by >30%

CLD Services - Rapid delivery of high-producing cell lines up to 8g/L

Rapid delivery of high-producing, stable cell lines up to 8g/L

Discover AbZelectPRO™

At Abzena we understand the importance of optimal cell line development (CLD). With over 20 years of expertise and a commitment to quality excellence, we can reduce your CLD timelines by >30%. Our fully integrated AbZelectPRO™ platform accelerates timelines and de-risks CLD programs with quick doubling times. It efficiently enables the rapid delivery of high-producing cell lines up to 8g/L for complex biologics or bioconjugates.

Generation of early-stage product from fast stable cell line pools enables us to confirm the Quality Target Product Profile (QTPP). In parallel, this material can be used to initiate formulation development and analytical method development, taking these key activities off the critical path. Material from stable cell line pools can also help accelerate process development for antibody-drug conjugates.

We have developed multiple cell lines that have progressed from process development into manufacture and through clinical trials. With years of experience in providing cell line development services, our team has successfully expressed biologics including antibodies, antibody fragments, bispecific antibodies, fusion proteins, growth factors and vaccines.

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AbZelectPRO™ Info Sheet

AbZelect™ & AbZelectPRO™: Enhanced Cell Line Development - Abzena

Find out how our enhanced CLD solution provides the foundation of biopharmaceutical development success and mitigates risk. For molecules such as mAbs, Fabs and Fc fusions, we streamline timelines using our AbZelectPRO™ platform methodology. For novel and complex molecules, our AbZelectPRO™ platform also allows us to design and develop a rapid, robust approach to your program. Download your copy of our info sheet here.

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What sets our cell line development services and solutions apart?

  • We offer an integrated cell line development process, shortening timelines to IND enabling material, supported by using fast stable pools to generate early-stage material for characterization, pre-formulation, analytics and lead molecule selection.
  • For complex biologic programs, we deliver increased productivity through our AbZelectPRO™ platform, which combines our existing CHO cell line with ProteoNic’s premium expression vector technology 2G UNic.
  • We maintain biosimilarity, critical for the regulatory, by developing your biosimilar cell line using the originator cell type.
  • Applying our technologies and experience in proteomics, protein engineering, bioconjugation and formulation development, we design novel subunit and conjugate vaccine candidates.
  • We have the flexibility and expertise to apply our processes to other proprietary host cell lines including; SP2-0, NS0, PER.C6, CHO-ZN, CHO BIOP3.
  • Streamline your biologics development program with our GMP-compliant cell line characterization approach.
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Discover AbZelectPRO™

About AbZelectPRO™

Move your cell line development efficiency forwards with our AbZelectPRO™ platform.

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AbZelectPRO™ Info Sheet

AbZelectPRO™ reduces the lead candidate sequence to RCB timeline.

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AbZelectPRO™ News

AbZelectPRO™ enables biopharma customers to reach their research cell bank in 10 weeks with 8g/L.

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Related Services

Biosimilar Cell Line Development

We help you maintain biosimilarity, critical for the regulatory approval of biosimilar products, by developing your cell line using the originator cell type.

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Cell Line Characterization

The safety and quality of your biologic product starts with the right cell line, discover our GMP-compliant cell line characterization methods.

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Research Cell Banking (RCB)

From transfection pools or non-clonal cell lines we apply our robust single cell cloning process to rapidly isolate and identify the most productive monoclonal populations.

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Vaccine Development

Applying our solutions and experience in proteomics, protein engineering, bioconjugation and formulation development, we design novel subunit and conjugate vaccine candidates.

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Analytical Development

Your product development program will be accelerated by leveraging our expansive in-house capabilities, technologies, and knowledge to deliver methods tailored to your molecule of interest.

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Process Development

We use our knowledge of cGMP manufacturing to transfer or develop the most effective processes for manufacturing at toxicology, clinical, and commercial scale.

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