Bioconjugates, ADCs & Chemistry - Abzena

Bioconjugates, ADCs & Chemistry

Accelerate your timeline to the clinic or the market with our expertise in complex chemistry and bioconjugation services.

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We are moving bioconjugates forward.

14+ conjugates in clinic including radiolabeled, oncology, and oligonucleotides.

2000+ conjugates developed for critical assays, and lead candidate selections with over 400 ADCs produced.

50+ bioconjugation programs scaled up to produce multi gram batches.

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Bioconjugates are sophisticated, powerful, and versatile. They have started to fulfill their therapeutic potential most prominently in oncology, with cytotoxic antibody-drug conjugates (ADCs) providing new, improved treatment options for cancer patients. We are a leading, fully integrated bioconjugate & ADC CDMO that offers forward-thinking, integrated bioconjugate development and manufacturing services, with streamlined end-to-end solutions like our advanced ThioBridge™ ADC design and development platform.

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Bioconjugates offer complex design and development challenges. A recent area of focus for Abzena to further improve the efficacy of Antibody-drug conjugates (ADCs), and address drug resistance issues, has been the development of dual-payload ADCs. Our streamlined solutions simplify the development process. Interconnected teams collaborate, offering full end-to-end support – all under one organization, accelerating your timelines to clinic and commercial manufacturing, specializing in:

  • Early de-risking & optimization
  • Linker payload design & synthesis
  • Process development & optimization
  • Formulation development
  • Analytical method development
  • Clinical to commercial manufacturing

Bioconjugation Capabilities

We ensure a robust and consistent bioconjugate manufacturing process from clinical to commercial scale. Our capabilities include:

  • Sartorius Sartoflow® Smart and Advance TFF systems for scale-up development and production in process development at volumes from 100mL – 50L and 0.1 – 2.1 m2 membrane surface area allowing for straightforward transfer to cGMP manufacturing
  • Sartorius Sartoflow® Alpha Plus SU and FlexAct® SU TFF systems for GMP manufacturing with volume ranges from 1 – 200L and up to 3.5 m2 membrane surface area
  • Full complement of AKTA FPLC™ systems in process development including an AKTA Pilot FPLC skid in process development capable of batch purification of more than 250g of bioconjugates in a day
  • AKTA Ready Gradient chromatography skid in GMP manufacturing suite capable of batch purification of greater than 1kg bioconjugate in a day
  • Conjugation reaction stirring capabilities include rocking motion mixers of volumes up to 50L and Sartorius LevMixer® pallet tanks from 50 – 1000L volume capacity
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What sets our bioconjugation services and solutions apart?

  • Leading end-to-end bioconjugation services across multiple modalities including ADCs, AOCs, Radioconjugates and more.
  • We are integrated in our approach to bioconjugate development combining design and production with functional assessment and biophysical characterization.
  • Through a comprehensive technology transfer process, we deliver a successful scale-up model to ensure a consistent bioconjugate manufacturing process from clinical to commercial.
  • We proactively collaborate with your team to de-risk the pathway of your bioconjugate to commercialization, ensuring manufacturability, moving quality medicine forward to patients.
  • We continue to pursue advances in technology, leverage our experience in a diverse range of bioconjugation platforms extending beyond ThioBridge™.
  • We expertly design and deliver solutions for small molecule intermediates including high potency chemistry, linker payload, payload-linker chemical intermediates.
  • Bioconjugation processes are developed and transferred to our cGMP manufacturing team minimizing process transfer challenges – here we can develop new innovative processes, when needed, to meet your program needs.
  • We develop the most effective processes for manufacturing at toxicology, clinical, and commercial scale using quality by design (QbD) principles.
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Specialized Bioconjugation Services

The Abzena ADC Toolbox

Building on the unmatched expertise of our scientists, the IP we’ve generated, and our advanced facilities in the UK and US, we have everything you need to implement fully integrated commercial bioconjugation & ADC development and manufacturing programs.

We offer access to genuine scientific experts, streamlined development solutions, interconnected teams and full end-to-end support – all under one organization.

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Bioconjugates: Increasing Diversity & Applications

Abzena Cambridge

Bioconjugation has emerged as a cornerstone technology, enabling precise drug delivery, whilst enhancing therapeutic efficacy and reducing adverse effects. In our latest whitepaper our bioconjugation experts have explored the variety of conjugate types that are now accessible, each designed to enhance medical outcomes in various therapeutic areas.

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Bioconjugates & Chemistry Services

Moving medicines created with ADCs, bioconjugates and linker payloads forward is where we excel. Abzena is the leading, fully integrated, bioconjugate contract development and manufacturing services provider through to commercialization.

Linker Payload

Supporting candidate ranking and lead selection, we determine the optimal design of linker payload architecture and profiling.

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Bioconjugate & ADC Design

We deliver tailored solutions for small molecule intermediates including high potency chemistry, payloads, linkers, and bioconjugates.

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Bioconjugate & ADC Development

We identify and de-risk your bioconjugate and ADC clinical candidates for development ensuring stage-specific milestones are met.

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Complex Chemistry & Polymers

We develop novel and improve synthetic routes for complex chemicals, cytotoxins, payloads, linkers, HPAPI and more.

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Analytics & Bioassays

We focus on giving you all of the rapid insight needed to help make informed decisions earlier during your biconjugate development journey.

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Immunogenicity Assays

Leverage our experience in delivering immunogenicity assays that help you better understand your bioconjugate or ADC earlier.

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Formulation Development

We develop comprehensive formulation development packages including stable liquid and lyophilized formulations for bioconjugates.

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Process Development & Optimization

Our experts collaborate together to develop quality, commercially viable processes ensuring seamless scale up through to commercial launch.

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cGMP Bioconjugate & ADC Manufacturing

We are experienced in offering reliable, predictable clinical to commercial cGMP bioconjugates & ADC manufacturing.

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Discover ThioBridge™

About ThioBridge™

Enhance your antibody-drug conjugate (ADC) development with our ThioBridge™ conjugation platform technology.

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ThioBridge™ Info Sheet

Rapidly move your ADC program to its next regulatory or clinical milestone, access our latest information on ThioBridge™.

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ThioBridge™ Case Study

We continue to pursue advances in technology, ThioBridge™ has been proven to rapidly enhance ADC design and development.

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Bioconjugation Insights

Whitepaper: Increasing Diversity & Applications of Bioconjugates

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Whitepaper: Designing, Selecting & Developing Bioconjugates

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Info Sheet: Streamlining Bioconjugation for ADC Development

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Info Sheet: Complex Chemistry for ADCs

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Info Sheet: Advanced Linker Payload Solutions

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Case Study: Fab-Oligo Conjugation Success

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