Bioconjugates, ADCs & Chemistry

Leveraging our experience in the synthesis of payloads, linkers, and payload-linker chemical intermediate constructs we enable rapid generation of structure activity relationships (SAR) of various linker combinations with your new payloads. We identify the most suitable linker for your ADC profile.

Our capabilities include:

• Sartorius Sartoflow^® Smart and Advance TFF systems for scale-up development and production in process development at volumes from 100mL – 50L and 0.1 – 2.1 m² membrane surface area allowing for straightforward transfer to cGMP manufacturing
• Sartorius Sartoflow^® Alpha Plus SU and FlexAct^® SU TFF systems for GMP manufacturing with volume ranges from 1 – 200L and up to 3.5 m² membrane surface area
• Full complement of AKTA FPLC™ systems in process development including an AKTA Pilot FPLC skid in process development capable of batch purification of more than 250g of bioconjugates in a day
• AKTA Ready Gradient chromatography skid in GMP manufacturing suite capable of batch purification of greater than 1kg bioconjugate in a day
• Conjugation reaction stirring capabilities include rocking motion mixers of volumes up to 50L and Sartorius LevMixer® pallet tanks from 50 – 1000L volume capacity