AbZelectPRO™: Enhanced Cell Line Development - Abzena

Ready to achieve more from your cell line? Discover AbZelectPRO™

Fully portable. No Abzena exit fees. No royalties. Single milestone payment at IND*. Discover our enhanced, mammalian cell line development platforms.

Achieve more from your cell line with our robust & flexible standalone or fully integrated AbZelectPRO™ platforms

CLD Services - Higher Productivity

Higher Productivity

High-quality mAb titers up to 10g/L

CLD Services - Proven Performance

Proven Performance

>90 INDs & 4 marketed drugs with Revvity GS KO & >20 INDs with 2G UNic® Vector

CLD Services - Rapid Timelines

Rapid
Timelines

Go from DNA to RCB in 10 weeks

CLD Services - No Extra Fees

No Extra
Fees

No Royalty Fees & No Exit Fees

It is never too early to research your mammalian cell line development (CLD) options. Opportunity is right here. Who can you count on for rapid and high yielding cell line development service? Abzena. We partnered with industry leading firms, Revvity and ProteoNic Biosciences, to offer you the most robust, stable cell line development platforms; AbZelectPRO™, AbZelectPRO™-KO (with GS Knockout) and AbZelectPRO™-KO+ (GS Knockout & ADCC+). Let’s move your CHO cell line forward.

Abzena are as committed to the downstream success and quality of your drug as you are. We have the expertise, partnerships, and capacity to move your mammalian cell line development program forward.

Standalone and integrated CLD models available with transparent pricing to IND with no royalty fees & no exit fees.

Revvity’s CHOSOURCE™ Glutamine Synthetase (GS) knockout cell line is a well-established, cGMP-manufactured CHO-K1-derived suspension cell line.

ProteoNic’s 2G UNic® vector boosts CHO cell protein yields by enhancing transcription, translation, and stability – enabling high titers and rapid cell line development.

* A Strategic Partner Fee is applicable if/when license holder transfers asset to another party.

What is AbZelectPRO™?

AbZelect™ & AbZelectPRO™: Enhanced Cell Line Development - Abzena


AbZelectPRO™ streamlines stable cell line development, enhances efficiency, and cuts timelines to IND application. Tailored for small to midsize biotechnology companies with antibody-based therapeutics, AbZelectPRO™ combines our existing CHO-K1 cell line with ProteoNic’s premium expression vector technology 2G UNic. It has been designed to accommodate diverse modalities and is supported by our strong analytical expertise.

Two next-generation Glutamine Synthetase (“GS”) knockout CHO-K1 expression systems, including a double knockout ADCC+ platform for afucosylated proteins are available, These further enhance speed, scalability, and flexibility for our biopharma customers. AbZelectPRO™-KO and AbZelectPRO™-KO+, are our GS knockout platforms. They are available as a standalone cell line development offering or as a fully integrated GMP program, with fully transparent pricing to IND with no royalty fees.

Download our Info Sheet now to discover more and contact us.

Stable Cell Line Development Platforms

AbZelectPRO™: Stable Cell Line Development Platform - Abzena
AbZelectPRO™-KO: Robust GS Knockout Cell Line Development Platform - Abzena
AbZelectPRO™-KO+: Advanced GS Knockout ADCC+ Cell Line Development Platform - Abzena

 

We can make the complex possible by supporting a broad range of diverse modalities including: Monoclonal & Bispecific Antibodies, Fc-Fusion Proteins, Antibody–Drug Conjugates, Multispecific Scaffolds, Complex Fusion Constructs & Glyco-Engineered Variants.

We understand your challenges

Are you faced with?

Looking for a proven biologics CDMO partner for a CLD program and beyond

Choosing clones based on initial productivity has lead to poor long-term performance

Researching a more streamlined approach with a focus on quality and minimizing risk

Trust isn’t given, it’s earned.

That’s why we’re proud to have over 20 years of CLD expertise, completing over 100 projects with >20 known cell lines in clinical programs for customers around the world.

Whatever your CLD challenge, you can be confident that Abzena are ready to help move your development program forward.

Contact Us

CLD Strategies that Reduce Timelines & Costs

Gain actionable insights into integrating innovative CLD technologies, de-risking strategies, and efficient development approaches to maximize the success of your biologics program.

Watch Abzena’s Brett Verstak, Director of Cell Line Development excerpt on AbZelectPRO™ and request full access to the on-demand webinar recording by clicking the button below.

What sets Abzena apart?

Access to Genuine Scientific & Technical Experts

We have over 20 years of experience in delivering solutions at each stage of the development lifecycle from early-stage research and discovery, through lead candidate selection, and onward into process development and GMP manufacture.

Unlike most other service providers, we can provide technical and scientific support that truly spans early-stage research through process development and GMP manufacturing under a single organization to better ensure that the TPP can be achieved. Our global scientific teams have extensive experience in overcoming some of the most challenging and complex biologic and bioconjugate programs, making us the perfect partner for novel and disruptive technologies that other biopharmaceutical CDMOs may shy away from.

Proactive Problem Solving to Ensure Downstream Success

Our experienced team is focused on getting it right from the start. We identify and address challenges early in drug design to better ensure downstream clinical and commercial success. We also have expertise in fixing and optimizing drugs in later stage development to rescue them from the drug development graveyard.

Diverse & Interconnected Expertise Under a Single Organization

With capabilities ranging from bioassays to cell line development, bioconjugation and clinical and commercial manufacturing, all under one organization, we can reduce the white space in the development path, which ultimately minimizes risk, reduces costs and accelerates timelines for our customers.

As an integrated service provider, we accelerate timelines through the ease of technical and materials transfer, and improved scheduling. Better workflows and processes can also be attained through improved knowledge transfer between internal multidisciplinary experts and the development of a deep understanding of the drug as it progresses from target to lead selection and process development and manufacture.

Driven by Innovation to Streamline Development

Our team is always seeking new ways to innovate and streamline development for our customers. Our extensive scientific capabilities and proprietary solutions like EpiScreen® 2.0, Composite Proteins™, Composite Human Antibodies™, AbZelectPRO™, ThioBridge™, and LabZient™ are designed to give your program the best chance of clinical and commercial success.

  • EpiScreen® 2.0 — an extensive suite of bioinformatic and primary human cell-based assays for immunogenicity assessment to inform of potential safety and efficacy risks in the clinic.
  • Composite Human Antibody™ — a platform used for designing safer, more effective, humanized antibodies.
  • Composite Proteins™ — a deimmunization technology that designs safer and more effective therapeutic proteins, devoid of human T cell epitopes, to minimize potential immunogenicity in patients without compromising activity.
  • AbZelectPRO™ — high-yielding cell line development (CLD) platform for accelerating the generation of production cell lines for manufacture of antibodies and recombinant proteins.
  • ThioBridge™ — a next-generation conjugation linker technology proven to enhance ADC development by overcoming issues with existing technologies to improve stability, potency, and efficacy.
  • LabZient™ — our analytical platform that combines predictive in-silico evaluation with laboratory methods to de-risk the application of platform analytical procedures and expedites the pathway to IND.

A history of successfully moving medicine forward

20+

years of complex biologics and bioconjugation services experience

2000+

conjugates developed for critical assays, and lead candidate selections with over 400 ADCs produced

50+

bioconjugation programs scaled up to produce multi gram batches

 

Each CLD program has a dedicated team, ensuring consistency and expertise transfer to our manufacturing facilities. Move forward from DNA to RCB in 10 weeks with 10g/L in high-performing titers and de-risk the path to IND with Abzena’s enhanced AbZelectPRO™ cell line development platform today.


For reliable, stable CHO cell line development, start a conversation with our scientific experts at Abzena today.