Rapid Developability Assessments​ For Lead Candidate Selection Case Study

Developability assessments have become an essential component of early drug discovery, playing a crucial role in selecting candidates that progress into IND-enabling and clinical studies. Such studies are designed to reduce the likelihood that a molecule with poor manufacturability properties will progress to the CMC stage, thereby de-risking the overall program. ​
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Developability studies can often be material-intensive. Abzena’s Developability Assessment platform has been designed to use small quantities of material. The assessment enables the rapid generation of data to inform downstream decisions, facilitating the comparison of multiple candidates.

In this case study Abzena’s experts assessed a panel of 7 mAb sequences supplied by one of our customers to identify the optimal choices for the best lead candidate. The mAbs consisted of combinations of different (but related) variable domains and/or different Fc regions (either IgG1 or IgG4 S241P).

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