AOC Conjugation – mAb with SiRNA Case Study

Access our latest antibody-oligonucleotide conjugate (AOC) case study on mAb SiRNA conjugate using maleimide conjugation via an engineered cysteine. The case study focused on a risk assessment process that identified with the proposed conjugation process, including disulphide scrambling during re-oxidation, SiRNA de-conjugation, and the chemical stability of the SiRNA linker maleimide unit.  After careful evaluation by Abzena’s scientific team, several solutions were offered that preserved material and improved the yield.

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