Antibody Discovery - Abzena

Antibody Discovery

We ensure you take the best antibody candidates forward.

Accelerating antibody discovery to candidate selection.

Over the past decade a number of antibody discovery technologies and platforms have emerged driven by a new era of antibody therapeutics including antibody-drug conjugates (ADCs). It has become more challenging to pick the right partner. Abzena’s antibody discovery experts specialize in building the foundations of your program. We start smart, setting you off on the right path to success.

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At Abzena we tailor our antibody discovery services to your needs. We deliver expert assessments of target molecules, immunization strategies and antibody screening cascades.

We apply innovative approaches and equipment to generate robust data that ensures optimal antibody discovery and supports the selection of the best antibody candidates for your drug development program.

Our Hybridoma MAX™ custom mouse monoclonal antibody discovery service maximizes the number of antibodies discovered through a dual, high-throughput screening platform that creates more candidates for development.

Antibody Discovery Methods

LabZient™: Rapid Analytical Data

Our antibody discovery methods ensure high affinity antibodies and where required cross-reactivity with the target, and include:

  • Flow cytometry to determine binding conditions
  • SPR analysis (Biacore) to determine affinity
  • In vitro assays to demonstrate functional activity
  • Epitope binning to characterize and select optimally designed mAbs

Hybridoma Sequencing

Our experts have generated 100s of hybridoma cell lines for our partners with our 100%-accurate sequencing platform, giving you the confidence that you are taking the correct sequence forward.

Having a 100% accurate sequence is crucial. Especially true if your antibody sequence is to be used for downstream activities such as recombinant antibody production or antibody humanization. Unlike some methods that can introduce mutations at the start, by using primers specifically designed to bind in the leader sequence, Abzena can determine the authentic start to an antibody variable domain. This simple difference can be critical to determining the sequence of a fully functional antibody.

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Antibody Design & Protein Engineering

Our team of antibody & protein engineering experts are well equipped to enhance and de-risk your program’s lead candidate through early development. Abzena have over 20 years of experience in antibody design and protein engineering at our Cambridge facility, and strive to reduce uncertainties in your project, maximizing the likelihood of success. By integrating advanced protein engineering knowledge with cutting-edge analytical techniques, we are able to create optimal drug candidates.

Antibody Design & Protein Engineering

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We evaluate the developability of your drug ensuring that the lead candidate you take forward has reduced liabilities and a de-risked development path.

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Drug development is a balancing act. Our 'Developability Assessment' de-risks early development, improving the potential for later success.

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Immunogenicity Assays

An integral service to biologic drug development. Immunogenicity assays help you better understand your drug earlier, allowing you to start smart, and finish fast.

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AbZelectPRO™: Enhanced Cell Line Development - Abzena

Let’s move medicine forward.

The leading biologics CDMO + CRO that de-risks and accelerates drug development. Let’s move medicine forward for patients in need.

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