Bispecific & Multispecific Antibodies

Bispecific antibodies combine multiple specificities into a single construct and many different ‘flavors’ of bispecifics have been developed, each with their own advantages and challenges, foremost amongst which is freedom to operate.

Whilst it may be that you already have a preferred bispecific design, if an optimal format has not yet been established, it may be desirable to take advantage of our experience by investigating a limited panel of simple ‘go to’ IP-free formats to explore the space.

Given the complexity of bispecifics, appropriate characterization and analysis is key. Traditional analytical techniques such as SDS-PAGE and SEC may not be sufficient and so techniques such as intact mass spectrometry and SEC-MALS need to be relied upon to assess correct bispecific formation. Additional characterization such as thermal stability profiling can provide further valuable information as to the developability potential of your molecules. Our experienced team will take the time to understand your bispecific and apply the most appropriate analytics to your molecule.

Characterization is just part of the story though. Once made, the molecules need to be tested in an appropriate assay. By working with our bioassay team, an appropriate assay can be designed to understand the functionality of the molecule and allow lead candidate selection.