Bioassays & Analytics

Early Phase Bioassays

Reliable bioassays that de-risk your product.

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Rapid, effective decisions during your early drug development journey to IND.

Bioassays play a critical role in the early stages of the drug development process providing essential insights into a drug’s potency, efficacy, and safety. Leveraging our decades of expertise in biologic drug development, analytics, and crucial early phase bioassays, you can be sure that only the most promising compounds progress onward toward the clinic.

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At Abzena, we have decades of expertise in delivering a range of reliable, early bioassays. These have been proven to help our customers streamline and de-risk their complex biologic or bioconjugate development programs.

We lead with an adaptable approach. We shorten the discovery phase, getting your product from bench-to-bedside faster, and with greater success. Our mission is to move medicine forward, ensuring your overall success in delivering vital medicines to patients.

We offer comprehensive bioassay services and solutions for: antibodies, conjugates, multi-specifics, fusions, fragments and agonist / antagonist activities.

An Adaptable Approach

Biologics Analytics & Bioassays - Abzena

Our unique approach focuses on developing phase-appropriate assays that are tailored to your program, giving you tools to make effective decisions during your drug development journey to IND and beyond.

Our broad array of bioassay platforms includes:

  • Luminescence, fluorescence, absorbance plate-based assays
  • Biacore™
  • Flow cytometry
  • Incucyte® live cell imaging (and other microscopy techniques)
  • Cytokine analysis (Luminex®, FluoroSpot)
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Early Phase Bioassays Info Sheet

Early Phase Bioassays - Abzena

By accurately measuring how a drug interacts with biological targets, bioassays help to identify potential therapeutic benefits and safety risks early on. This streamlines the development process. Allowing for more intelligent decisions.

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Comprehensive Bioassay Solutions

Our comprehensive bioassay solutions include both established assays and customized assays that match your individual needs. From discovery-themed assay applications that support target validation and hit-to-lead screening through design, development and manufacturing, our full suite of analytical assessments helps you start smart and finish fast.

Discovery

  • In vitro/gene protein expression
  • Biomarker profiling: Surface markers, cytokine production
  • Target binding and affinity
  • Functional activity: reporter assays and primary cell assays

Design & Developability

By providing fully integrated design and developability strategies under a single organization, Abzena works from a lens of adaptability by streamlining upstream and downstream processes that have traditionally presented time-stealing challenges to our customers.

 

Specificity and Tissue Profiling

  • On-target binding to cell lines or primary disease tissue
  • Off-target binding to primary immune cells or normal tissue
  • Polyspecificity assessment

Mode of Action (MoA)

  • Ligand binding and competition
  • Internalization and trafficking
  • Viability assessment — 2D/3D viability assay, cell cycle arrest,
    apoptosis, bystander effect, co-culture cell killing
  • Gene and protein knockdown
  • Fc effector function – ADCC, ADCP & CDC
  • MLR & superantigen proliferation and cytokine analysis
  • PK & PD assessment
Immunogenicity and Safety Assessment

Immunogenicity risk assessment of proteins using:

  • EpiScreen™ 2.0 time course assay
  • EpiScreen™ 2.0 DC:T cell assay

Identification of immunogenic sequence “hot spots” using:

  • In silico assessment by iTope-AI
  • MHC Class II associated peptide proteomics (MAPPs)
  • EpiScreen™ 2.0 T cell epitope mapping

Safety Assessment of Proteins with Potential to Induce Cytokine Storm

  • Cytokine Release Assay

Manufacturing and Potency Batch Release

  • Development of ELISA or cell-based binding assays
  • Development of MoA-reflective potency assays
  • Assay validation and GMP potency testing
“I had the pleasure of working with Abzena’s Cambridge, UK team on a variety of in vitro pharmacology projects, ranging from cell-based assays to Biacore kinetic analysis. I found the team to be professional, reliable, and excellent partners. Given the virtual nature of the company I work for, we rely on strong partnerships in order to produce quality data to allow us to make strategic program decisions. The Abzena team was instrumental in providing timely, high-quality data that impacted our decision-making. I would highly recommend this team for all your preclinical pharmacology needs.”

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