Rapid Developability Assessments to Assist Lead Candidate Selection

At the recent Biologics US event in San Diego, our Sr. Director of Bioassays, Dr Erika Kovacs presented a poster entitled, “Rapid Developability Assessments to Assist Lead Candidate Selection.”

The poster highlights our robust developability platform, which integrates in silico approaches with characterization and stability studies to determine the selection of the best candidate to progress.

Using a panel of 7 mAb sequences that were expressed in ExpiCHO by transient transfection and characterized by SDS-PAGE and analytical SEC before assessment, the poster details the different computational tools employed to identify sequence liabilities, and immunogenicity risks, while advanced biophysical techniques evaluated manufacturability and stability.

Poster authors include: Robert Cunningham, Judit Csapo, Emily Mallet, Marta Bussee, Marina Leal, Patrick Lynch, Aaron Hearn, Erika Kovacs, Williams McDowell, Rob Holgate