Join Abzena’s VP of Business Development, Sudha Krishnan at the upcoming January 15th PBSS focused on the quantitative assessment and translation and next-generation and novel modalities.

Event Description

Predicting pharmacokinetics (PK), pharmacodynamics (PD), and target engagement in tissues that cannot be sampled clinically is a major challenge in drug development. This workshop will present current modeling and experimental strategies to assess the biodistribution of large molecule therapeutics, such as antibodies, peptides, and nucleic acid-based medicines. A key focus will be on translating these quantitative assessments from preclinical models to support and accelerate clinical development. The session is intended for scientists and researchers working in preclinical and clinical PK/PD.

Key Topics Covered:

• PBPK modeling of antibody drug conjugates (ADCs) and T-cell dependent bispecifics in heme and solid tumor indications
• Mechanistic modeling of oral administered protein therapeutics for gut site of action
• PK/PD of nucleic acid based medicines delivered directly to the central nervous system
• Brain delivery and biodistribution of systemically administered antibodies
• Pre-clinical imaging to assess biologic biodistribution

Schedule a meeting with Sudha at the event