Bioconjugates (ADCs, AOCs, RDCs) & Chemistry

Bioconjugates are hybrid molecules linking biological and chemical components. They include antibody-drug conjugates (ADCs) and antibody-oligonucleotide conjugates that can be used in highly targeted therapies.

Bioconjugation or bioconjugate chemistry as it can also be referred to, is the chemical process of precisely linking two (or more) molecules, where at least one component is a biologically active molecule with a potent payload. The goal of bioconjugation is to create a new and stable targeted therapy, a ‘bioconjugate’ such as an ADC or AOC.

Yes, Abzena has experience through multiple AOC programs, with expertise in antibody formats (mAbs, Fabs, VHHs), analytics and biological assessment such as cell binding, trafficking and gene knock-down.

ADCs and AOCs share structural similarities. They both combine antibodies with functional payloads. Their development processes differ significantly due to the complexity of oligo payloads in AOCs. These differences present distinct technical, analytical and regulatory challenges that experienced developers like Abzena must address.

The process starts by defining the molecule’s function and development stage, then designing tailored conjugate panels to guide discovery and optimization.

For AOCs, regulatory frameworks are continuing to evolve. Developing AOCs involves navigating a regulatory landscape that is incomplete. The FDA and EMA classify oligos differently. The unique characteristics of AOCs – particularly their oligo payloads – present challenges that existing frameworks do not fully address. This gap requires experienced bioconjugate developers such as Abzena to adopt proactive and scientifically rigorous approaches.

Yes, if a suitable handle is available for linker attachment, Abzena can conjugate your payload to a monoclonal antibody and guide you through the process.

Yes, Abzena offers end-to-end tech-transfer support for ADC, AOC, and other conjugation programs, helping companies onshore their processes while maintaining consistency, quality, and scalability.