In vitro assessment of Fc functional activity: ​A broad range of solutions for diverse assay needs

The success of many cancer therapeutics lies in their ability to induce ADCC, ADCP and CDC against specific targets, thus, appropriate assessment is crucial before progressing a drug into the clinic. Demonstrating lack of unwanted effector functions is also important for safety purposes.

Access our recent poster from Festival of Biologics to get an understanding of the key aspects for developing successful Fc effector functional assays and weigh up the benefits and challenges of a panel of assay formats for different purposes. We present options for choosing the most suitable target cell lines, effector cells and appropriate controls.

Click here to download the poster

Poster Authors: Rosa Gonzalez- Serrano, Erika Kovacs, Arron Hearn, Robert Holgate, Campbell Bunce

About Abzena

Abzena has developed a comprehensive suite of assays to support the characterization of the Fc-mediated activity of antibodies, Fc fusions or ADC products.

Each assay can be tailored to the specific requirements of your project and our team of experts will work with you to provide solutions to suit your specific needs, considering aspects such as mode of action, assay sensitivity, complexity and regulatory requirements.