Upstream Production Associate - Abzena

Upstream Production Associate

Location: San Diego, CA
Area: Manufacturing

Position Responsibilities:

  • Assist the PD Lead Associates, Associate Scientists, and Scientists with the development work to develop scalable and robust processes on accelerated timelines.
  • Perform manufacturing and process development activities for projects and products in collaboration with others.
  • Assist with technical transfer of upstream manufacturing processes from clients and between Process Development and Manufacturing groups.
  • Assist in scale-up calculations for varying scales of the process – up to cGMP scale.
  • Assist in cell culture protein production using aseptic techniques
  • As needed, assists in protein production under cGMP standards for clinical trial material.
  • Capable of making media and buffers following protocols and procedures.
  • Assists in production-scale cell culture operations for protein production and manufacturing of final products.
  • Assists in the documentation of observations and collecting data for analysis. Capable of data management.
  • Conduct activities in support of production schedules and objectives as directed by senior staff.
  • Maintains records to comply with regulatory requirements and assists with in-process testing.
  • Maintain lab organization and cleanliness by regularly stocking supplies and managing supply inventory.
  • Assemble and autoclave tubing assemblies.
  • Knowledge of quantitative analytical methods.
  • Represents departmental activities as needed, including project teams, training, and evaluation of new technologies

 

General Responsibilities:

  • Operates to the highest ethical and moral standards.
  • Complies with Abzena’s policies and procedures.
  • Adheres to quality standards set by regulations and Abzena policies, procedures and mission.
  • Communicates effectively with supervisors, colleagues and subordinates.
  • Ability to participate effectively as a team player in all aspects of Abzena’s business.
  • Travels as needed to attend professional conferences, and train on new technologies.

 

Qualifications/Skills Required:

  • AA/AS or BA/BS degree that included laboratory work in a chemistry, biology, chemical engineering or related field plus 1-3 years in a laboratory environment.
  • Basic knowledge of protein production.
  • Skill with single-use technologies or cell culture parameters (for various cell lines) and nutrient requirement in shaker flasks and disposable bioreactors up to 500 L for production.
  • Skill with Microsoft Office suite
  • Ability to follow detailed instructions and to maintain accurate records and notes.
  • Ability to work effectively in a team environment.
  • Ability to successfully perform multiple tasks, when required.
  • Skills in problem solving and troubleshooting.
  • Ability to safely operate production equipment in accordance with established practices.
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