Manager - Bioconjugation - Abzena

Manager – Bioconjugation

Location: Cambridge, UK
Area: Bioconjugation

We have a vacancy for an experienced bioconjugation senior scientist to join our Bioconjugation Chemistry team in Cambridge (UK).  In this lab-based role you will be working as part of a team on client-facing, short-term projects from the outset and will lead a small team of scientists in a fast-paced and supportive environment.

Abzena provides the most complete set of solutions in integrated early discovery to mid-phase biotherapeutic and ADC drug development services in the pharmaceutical industry. Working with a varied range of customers from academic groups, small biotech and big pharma and on a diverse range of drug types from antibodies, fusion proteins and bioconjugates, Abzena supports the development and manufacture of better treatments for patients. As a testimony of its outstanding expertise and quality of its services in bioconjugates early development, Abzena won the best CRO award at the World ADC conference in 2020.

The Bioconjugation Group in Abzena Cambridge (UK) provides conjugation solutions to support partner antibody drug conjugate (ADC), oligonucleotide conjugate, PEGylation and other conjugate development programs. Using established conjugation chemistries and its next-generation conjugation platform ThioBridge® with access to a wide range of cargo’s, we design, synthesise and produce ADC candidates evaluated with support from the Design and Developability Groups for lead candidate selection.

Ideally, you will have a PhD or MSc (or a lower level of qualification and relevant experience) in Chemistry/Protein Biochemistry or related science discipline with strong laboratory skills and experience in an industrial or commercial environment. Relevant skills required include an in-depth understanding of, and practical research experience with bioconjugation of small molecules (e.g. cytotoxic drugs, fluorescent labels, oligonucleotides) and polymers to antibodies and proteins using a range of linker chemistries, purification using automated systems (AKTA) and membrane ultrafiltration (TFF), and analytical characterisation techniques such as column chromatography (HIC, SEC, IEX), UV-Vis spectrophotometry, microfluidics (CE-SDS, iCEF) and LC-MS. As a confident IT user, you will be familiar with MS Office, and specialist software including Chromeleon, Unify, MassLynx and ChemDraw. You will have a good understanding of the ADC field including drug development process.

You will be able to work both independently and as part of a team, have good planning and organising skills. In addition, you will have a high level of attention to detail and be able to identify and analyse and resolve routine and complex problems. You will be proactive and independent, with a high level of autonomy and initiative. You will demonstrate ability to communicate clearly both orally and in writing, keeping team and management informed. You will contribute to the group development effort undertaking advanced research, managing client projects and interactions in a professional manner and actively leading a small team in an approachable, adaptable and supportive way.

In return, we can offer you a competitive salary and benefits package and a collaborative, varied and challenging environment where you will be encouraged to step outside your comfort zone and develop your career.

Must be eligible to work in the UK.

Job description

  • To independently design and carry out routine and complex experiments as necessary
  • To perform complex/novel techniques without supervision
  • To manage own work schedule to ensure tasks are met within the expected timeframe
  • To contribute to the planning/development of complex experiments of line reports
  • To analyse and interpret own data and those of line reports
  • To be responsible for the quality of own work and those of line reports
  • To prepare data for, contribute to and lead the drafting of reports and presentations
  • To contribute to and lead internal and client meetings
  • To manage individual projects or multiple studies
  • To draft and contribute to Quality and Controlled documents
  • To undertake any other duties relevant to the position and level
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