Assessment of Fc-mediated Functional Activity for the Development of Complex Biologics and Bioconjugates

Access the on-demand recording to hear expert insights from our Sr. Director of Bioassay, Dr Erika Kovacs, and Sr. Manager of Bioassay, Dr Rosa Gonzalez-Serrano, as they review strategies for phase-appropriate assessment of Fc-mediated functional activity and present new developments for complex modalities.

The success of many cancer therapeutics lies in their ability to induce cytotoxicity by NK cells (antibody-dependent cellular cytotoxicity (ADCC)), phagocytosis (antibody-dependent cellular phagocytosis (ADCP)) and complement-dependent cytotoxicity (CDC) against specific targets; therefore, appropriate assessment is crucial before progressing a drug into the clinic.

Importantly, demonstrating the lack of unwanted effector functions is required for safety purposes. During this webinar, the expert speakers will consider the key aspects for developing successful Fc-mediated functional assays and will review the benefits and challenges of a panel of assay formats for different purposes.

They will also present options for choosing the most suitable target cell lines, effector cells and appropriate controls. Moreover, they will showcase studies on how rigorous data trending leads to reliable assays and how more complex formats, such as how real-time spheroid cytotoxicity assays contribute to understanding the mode of action and selecting the most promising lead.

Watch the webinar to obtain an overview of how Fc-mediated functions (or lack of) are essential to the success of biologic drugs and how best to evaluate these functions.

What You Will Learn

  • Best approaches to assess Fc function (ADCC, ADCP and CDC) for drug discovery and development programs
  • Benefits of working with experienced clinical research organizations (CROs) to ensure high-quality and reliable data are obtained
  • Benefits and challenges of complex assay formats like real-time spheroid cytotoxicity assays
  • How to design and develop successful Fc-mediated functional assays, including the selection of target cell lines, effector cells and appropriate controls

Access the On-Demand Recording

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