More information on Abzena’s Composite Protein™ technology. Protein Deimmunisation Technical Flyer

More information on our antibody humanisation and deimmunisation technology, including a case study on the deimmunisation[...]

A deimmunised form of the ribotoxin, α-sarcin, lacking CD4+ T cell epitopes and its use as an immunotoxin warhead

Fungal ribotoxins that block protein synthesis can be useful warheads in the context of a targeted immunotoxin. α-Sarcin[...] Read more

The INNs and outs of antibody nonproprietary names

http://www.tandfonline.com/doi/full/10.1080/19420862.2015.1114320 Tim D. Jones, Paul J. Carter, Andreas Plückthun, Max[...] Read more

A comparison of the ability of the human IgG1 allotypes G1m3 and G1m1,17 to stimulate T-cell responses from allotype matched and mismatched donors.

Carl I. Webster, Christine J. Bryson, Edward A. Cloake, Tim D. Jones, Mark J. Austin, Anette C. Karle, Sebastian[...] Read more

Characterisation of a novel anti-CD52 antibody with improved efficacy and reduced immunogenicity

Holgate RGE, Weldon R, Jones TD, Baker MP (2015) Characterisation of a Novel Anti-CD52 Antibody with Improved Efficacy[...] Read more

Small Amounts of Sub-Visible Aggregates Enhance the Immunogenic Potential of Monoclonal Antibody Therapeutics

Maryam Ahmadi, Christine J. Bryson, Edward A. Cloake, Katie Welch, Vasco Filipe, Stefan Romeijn, Andrea Hawe, Wim[...] Read more

Immunogenicity of protein therapeutics The key causes, consequences and challenges

Matthew P. Baker,* Helen M. Reynolds, Brooke Lumicisi and Christine J. Bryson, Self/Nonself, Volume 1, Issue 4, 2010[...] Read more

Deimmunization of monoclonal antibodies

Jones TD, Crompton LJ, Carr FJ, Baker MP. Methods Mol Biol. 2009;525:405-23, xiv. doi: 10.1007/978-1-59745-554-1_21.[...] Read more

Circumventing immunogenicity in the development of therapeutic antibodies.

Holgate RG, Baker MP, IDrugs. 2009 Apr;12(4):233-7. Abstract The development of anti-therapeutic antibody immune[...] Read more

Overcoming the immunologic response to foreign enzymes in cancer therapy

Expert Rev Clin Immunol. 2005 Nov;1(4):549-59. doi: 10.1586/1744666X.1.4.549. Chester KA, Baker M, Mayer A. Abstract[...] Read more

Identification and removal of a promiscuous CD4+ T cell epitope from the C1 domain of factor VIII

Jones TD, Phillips WJ, Smith BJ, Bamford CA, Nayee PD, Baglin TP, Gaston JS, Baker MP. Abstract BACKGROUND: The[...] Read more