Senior Scientist – Bioconjugation

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The Bioconjugation Group in Abzena Cambridge (UK) provides conjugation solutions to support partner antibody/peptide drug/oligonucleotide conjugate, PEGylation and other bioconjugate development programs. Using established as well as novel conjugation chemistries and its proprietary conjugation platform ThioBridge® with access to a wide range of cargo’s, the Bioconjugation Group designs, synthesises and produces ADC candidates that are evaluated with support from the Design and Developability Groups for lead candidate selection. Our team of highly skilled and passionate bioconjugation chemists has access to state-of-the-art laboratories on the Babraham Research Campus in Cambridge, equipped with the latest high containment capabilities and a range of automated LC systems to develop appropriate purification approaches for the production of ADCs and bioconjugates. The Bioconjugation Group works closely with the Analytical Group with direct access to instrumentation such as UPLC chromatography and advanced mass spectrometry systems to support analytical characterisation of bioconjugates.An exciting opportunity has opened to join the group at Senior Scientist level for a bioconjugation chemist who will help us deliver for high-paced client projects. The ideal candidate will have a background in bioconjugation chemistry with strong laboratory skills and previous industrial experience.

MAIN DUTIES AND RESPONSIBILITIES:

Technical / Professional Perform routine laboratory bioconjugation experiments to support client-based projects;Perform the synthesis and conjugation of small molecules (e.g. cytotoxic drugs, oligonucleotides, fluorescent labels) and polymers to antibodies, novel scaffolds, proteins and peptides using a range of linker chemistries;Carry out purification of antibody and protein conjugates by column chromatography (e.g. HIC, SEC, IEX) using automated systems (AKTA) and membrane ultrafiltration (TFF);Characterise antibody and protein conjugates using analytical chromatography techniques (HIC, SEC, IEX), UV-Vis spectrophotometry, microfluidics (CE-SDS, iCEF) and LC-MS;Take part in laboratory housekeeping and contribute to maintenance of laboratory equipment;Carry out tasks accurately following protocols (SOPs or WI) and in compliance with Health and Safety procedures;Perform routine interpretation of analytical results;Keep accurate records and document experimental results in electronic laboratory notebooks;Prepare presentations and present results at internal meetings and client meetings;Contribute to writing of client reports. Personal / Team Manage their own work and tasks independently;Keep line manager and Group Leader informed of work progress in a timely fashion;Proactively support other laboratory scientists.

KEY COMPETENCIES

Qualifications/Experience

Essential:

Minimum of Bachelor’s or Master’s degree in Chemistry / Protein Biochemistry or related science discipline

Desirable:

At least 2 years experience in an industrial environment, or PhD in a relevant discipline
Knowledge or experience of protein chemistry and synthetic organic chemistry
Experience with oligonucleotide conjugates synthesis

Skills & Knowledge

Essential:
Excellent technical skills
Ability to plan own work in order to meet the project objectives in a timely fashion
Demonstrates excellent interpersonal and communication skills
Ability to exercise a high level of initiative
Ability to identify and analyse routine problems and issues

Desirable:
A good understanding of the research environment in biotech and pharma industry

Diversity, inclusion and belonging

Abzena for everyone; bring your whole self to work.

You belong. Building an inclusive culture that fosters, empowers, and celebrates the diverse voices of our employees, we embrace your thoughts, experiences, and talents. It is our belief that the more inclusive we are, the better we work.We’re an inclusive employer, and we care about diversity in our teams. Let us know in your application if you have accessibility requirements during the recruitment process.We put people first, understanding your needs and respecting your rights. This includes respecting your rights to data protection, as protected in law. We’ll always conduct our work with your privacy in mind. This means collecting as little personal data as possible, storing it securely and being clear about how we’ll use it

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