Bioconjugates, ADCs & Chemistry - Abzena

Bioconjugates, ADCs & Chemistry

Accelerate your timeline to the clinic or the market with our expertise in complex chemistry and bioconjugation services.

Download Brochure Discover ThioBridge™

We are moving bioconjugates forward.

14+ conjugates in clinic including radiolabeled, oncology, and oligonucleotides.

2000+ conjugates developed for critical assays, and lead candidate selections.

50+ bioconjugation programs scaled up to produce multi gram batches.

Contact Us

Bioconjugates & Antibody-Drug Conjugates (ADCs) offer a complex development and manufacturing challenge. Abzena’s experience in providing bioconjugation services has produced over 400 ADCs. Our complete end-to-end service offering simplifies the development process, and accelerates timelines to reach the clinic or market.

Contact Us

We are a leading, fully integrated bioconjugates & ADCs CDMO. We offer expert development and manufacturing services, and end-to-end bioconjugation solutions such as our ThioBridge™ ADC development platform.

Our end-to-end services for bioconjugates & ADCs provide you:

  • Early de-risking & optimization
  • Process development & optimization
  • Formulation development
  • Analytical method development
  • Linker payload design & synthesis
  • Clinical to commercial manufacture

Streamlining ADC, linker payload & bioconjugate services

The Abzena ADC Toolbox

Our bioconjugation process development group is purpose built for the optimization and scale-up of your ADCs and bioconjugates. Building on the unmatched expertise of our scientists, the IP we’ve generated, and our advanced facilities in the UK and US, we have everything you need to streamline and implement fully integrated commercial bioconjugation & ADC development and manufacturing programs.

Download Info Sheet View ADC toolbox

What sets our bioconjugation services expertise apart?

  • Through a comprehensive technology transfer process, our scientific experts deliver a successful scale-up model to ensure robust and consistent manufacturing process from clinical to commercial scale.
  • We are proactive and collaborate with your team to de-risk the pathway to commercialization, ensuring manufacturability, and deliver a quality medicine to the patient.
  • We develop the most effective processes for manufacturing at toxicology, clinical, and commercial scale using quality by design (QbD) principles.
  • We continue to pursue advances in technology, our unique ThioBridge™ conjugation technology has been proven to enhance ADC development, improving stability, potency, and efficacy.
  • We have 20+ years of experience designing and delivering tailored solutions for small molecule intermediates including high potency chemistry, linker payloads, payload-linker chemical intermediates, bioconjugation and ADCs.
  • We offer full end-to-end services across multiple modalities including ADC’s and AOC’s (Antibody-Oligonucleotide Conjugates).

Bioconjugates & Chemistry Services

Linker Payload

Supporting candidate ranking and lead selection, we determine the optimal design of linker payload architecture and profiling.

Learn More

Bioconjugate & ADC Design

We deliver tailored solutions for small molecule intermediates including high potency chemistry, payloads, linkers, and bioconjugates.

Learn More

Bioconjugate & ADC Development

We identify and de-risk your bioconjugate and ADC clinical candidates for development ensuring stage-specific milestones are met.

Learn More

Complex Chemistry & Polymers

We develop novel and improve synthetic routes for complex chemicals, cytotoxins, payloads, linkers, HPAPI and more.

Learn More

Analytics & Bioassays

We focus on giving you all of the rapid insight needed to help make informed decisions earlier during your biconjugate development journey.

Learn More

Immunogenicity Assays

Leverage our experience in delivering immunogenicity assays that help you better understand your bioconjugate or ADC earlier.

Learn More

Formulation Development

We develop comprehensive formulation development packages including stable liquid and lyophilized formulations for bioconjugates.

Learn More

Process Development & Optimization

Our experts collaborate together to develop quality, commercially viable processes ensuring seamless scale up through to commercial launch.

Learn More

cGMP Bioconjugate & ADC Manufacturing

We are experienced in offering reliable, predictable clinical to commercial cGMP bioconjugates & ADC manufacturing.

Learn More

Latest News & Insights

Articles

World Pharma Today: Powering Through Into 2025 With A Strong Foundation

Read More

News

Abzena Strengthens Board with Appointment of Biopharma Industry Leader, Dr Moncef Slaoui

Read More

Articles

MHC-Associated Peptide Proteomics: Immunogenicity and Vaccine Design

Read More